Pigment epithelium-derived factor in urine may be a screening marker for diabetic nephropathy
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| Conditions: General Urology and Renal Transplant |
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Pigment epithelium-derived factor (PEDF) serum levels have been shown to correlate to clinical parameters of diabetic nephropathy (DN). The association between PEDF in urine (uPEDF) and diabetic nephropathy in type 2 diabetes mellitus patients was investigated in 1 animal and 2 human studies. The first human study was a cross-sectional study comparing 228 type 2 diabetes patients vs. 49 healthy controls. The second was a longitudinal study of 42 type 2 diabetes patients with hypertension and microalbuminuria on 6-month irbesartan therapy. uPEDF was measured using ELISA in the human studies. The animal study compared PEDF in the kidney and urine of healthy vs. diabetic rats on irbesartan or on a high-fat diet. In the cross-sectional study, uPEDF levels were significantly higher in patients with diabetic nephropathy vs. controls and were correlated with microalbuminuria. In addition, uPEDF was also significantly higher in patients with microalbuminuria and diabetic retinopathy. In the longitudinal...
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